Target Organ Toxicity
Volume 2| By: | Gerald M. Cohen |
| Publisher: | Taylor & Francis |
| Print ISBN: | 9780367258719 |
| eText ISBN: | 9781000697384 |
| Edition: | 1 |
| Copyright: | 1986 |
| Format: | Reflowable |
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First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.