LC-MS in Drug Bioanalysis
| By: | Q. Alan Xu; Timothy L. Madden |
| Publisher: | Springer Nature |
| Print ISBN: | 9781461438274 |
| eText ISBN: | 9781461438281 |
| Edition: | 1 |
| Copyright: | 2012 |
| Format: | Reflowable |
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Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.